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The simulators are supported by a large library of freeware assets which can be downloaded from the N3V servers, referred to as Download Station (DLS). Unless users purchase a First Class Ticket with real money, download speeds for the DLS (both in Content Manager and directly through File Transfer Protocol on the Trainz website) are throttled, which tends to be a point of contention in the Trainz community. PaintShed is a simple program for aiding and easing the process of 'reskinning' traincars, altering their livery, by recoloring and adding new heraldry to Trainz locomotives and other rolling stock. The Content Manager (CM) module is a Windows program that allows management of the in-game database files. It was renamed under the name of Content Manager Plus (CMP) in TRS2006.
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Trainz Railway Simulator 2006 (known as Trainz Railroad Simulator 2006 in the USA), or TRS2006, was a transitional release, incorporating the stable Auran JET based TRS2004 GUI modules with only some graphics improvements, but introducing the data base manager Content Manager Plus (CMP) as a new core technology. ContentManager.exe (now called just CM) combines data base management, and secure FTP upload and download facilities and special user definable filters all in one integrated system. By defining a good filter, the user could 'selectively not see' the clutter of regional items in the Surveyor asset selection menus saving user time when world building. This important filtering feature was further improved in Trainz 2009, becoming far more powerful and easier to use. In addition to these improvements, several new routes were included, such as Hawes Junction (representing a small section of the Settle and Carlisle Railway and serving as a demo for TC3), Toronto Rail Lands 1954 (representing Toronto's sprawling railyard in 1954), and Marias Pass Approach (representing the BNSF Marias Pass line between Shelby, Montana and Cut Bank, Montana and serving as a demo for the full Marias Pass payware route). TRS2006 was published in September 2005, and the base release with its single service pack formed the core of the regional releases (most are joint ventures with 'Trainz Partners' combining payware content provider's products with the base Trainz software) over the next four years until the introduction of new technologies in TC3 and TRS2009. In Germany, it was published by Bluesky-Interactive, as ProTrain Perfect.[citation needed]
The content from Trainz Classics 1 and 2 were later released as built-content for TS2009 and TS2010, and can be downloaded from the DLS for all future games. Trainz Classics 3 was re-released as an expansion pack for all subsequent games as the Settle & Carlisle Route, with extra content added from the original release (some of the Mark 1 coaches in BR Blue were also included by default in these versions due to being used in the consists of trains on the built-in East Coast Main Line routes).
The function of a non-protein-coding RNA is often determined by its structure. Since experimental determination of RNA structure is time-consuming and expensive, its computational prediction is of great interest, and efficient solutions based on thermodynamic parameters are known. Frequently, however, the predicted minimum free energy structures are not the native ones, leading to the necessity of generating suboptimal solutions. While this can be accomplished by a number of programs, the user is often confronted with large outputs of similar structures, although he or she is interested in structures with more fundamental differences, or, in other words, with different abstract shapes. Here, we formalize the concept of abstract shapes and introduce their efficient computation. Each shape of an RNA molecule comprises a class of similar structures and has a representative structure of minimal free energy within the class. Shape analysis is implemented in the program RNAshapes. We applied RNAshapes to the prediction of optimal and suboptimal abstract shapes of several RNAs. For a given energy range, the number of shapes is considerably smaller than the number of structures, and in all cases, the native structures were among the top shape representatives. This demonstrates that the researcher can quickly focus on the structures of interest, without processing up to thousands of near-optimal solutions. We complement this study with a large-scale analysis of the growth behaviour of structure and shape spaces. RNAshapes is available for download and as an online version on the Bielefeld Bioinformatics Server.
We sought to evaluate the rate of conversion of Society for Maternal-Fetal Medicine (SMFM) annual meeting abstract presentations to full manuscript publications over time. Full manuscript publications corresponding to all SMFM oral abstracts 2003 through 2010 inclusive, and SMFM poster abstracts in 2003, 2005, 2007, and 2009 were manually searched in PubMed. An abstract was considered to "match" a full publication if the abstract and publication titles as well as main methods and results were similar and the abstract first author was a publication author. In cases of uncertainty, the abstract-publication match was reviewed by a second physician researcher. Time to publication, publication rates over time, and publication rates among US vs non-US authors were examined. PubMed identification numbers were also collected to determine if >1 abstract contributed to a manuscript. Data were analyzed using Wilcoxon rank sum, analysis of variance, t test, and logistic regression. In all, 3281 abstracts presented at SMFM over the study period, including 629 orals (63 main plenary, 64 fellows plenary, 502 concurrent), were reviewed. Of 3281, 1780 (54.3%) were published, generating 1582 unique publications. Oral abstracts had a consistently higher rate of conversion to publications vs posters (77.1% vs 48.8%, P
The NASA-ADS Abstract Service provides a sophisticated search capability for the literature in Astronomy, Planetary Sciences, Physics/Geophysics, and Space Instrumentation. The ADS is funded by NASA and access to the ADS services is free to anybody worldwide without restrictions. It allows the user to search the literature by author, title, and abstract text. The ADS database contains over 3.6 million references, with 965,000 in the Astronomy/Planetary Sciences database, and 1.6 million in the Physics/Geophysics database. 2/3 of the records have full abstracts, the rest are table of contents entries (titles and author lists only). The coverage for the Astronomy literature is better than 95% from 1975. Before that we cover all major journals and many smaller ones. Most of the journal literature is covered back to volume 1. We now get abstracts on a regular basis from most journals. Over the last year we have entered basically all conference proceedings tables of contents that are available at the Harvard Smithsonian Center for Astrophysics library. This has greatly increased the coverage of conference proceedings in the ADS. The ADS also covers the ArXiv Preprints. We download these preprints every night and index all the preprints. They can be searched either together with the other abstracts or separately. There are currently about 260,000 preprints in that database. In January 2004 we have introduced two new services, full text searching and a personal notification service called "myADS". As all other ADS services, these are free to use for anybody. 2ff7e9595c
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